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2 year(s) ago

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Lytics for submassive PE?

45 yo, SOB x 3 months, CT showing bilateral saddle emboli. Stable vitals, asymptomatic at rest. EKG showed a new right axis deviation, BNP 1000+, CT did not show RV dilation, Trop normal. 1. BNP, Trop, EKG and CT findings variably predict RV dysfunction. Would anyone treat the patient with lytics before echo? 2. If echo showed RV dysfunction, would you lyse?

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2 year(s) ago
Good case.  There definitely is evidence for RV dysfunction with the EKG/elevated BNP.  I would think about lytics and would consider them if the patient decompensated and became hemodynamically unstable.  I personally would not push lytics in a patient with normal vitals/asymptomatic at rest--especially with a 3 month history of symptoms.  Any cowboys out there?
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2 year(s) ago
It seems more like there is discussion and guidelines on lytics for submassive PE than evidence.  The argument for lytics is summarized very well here (http://emupdates.com/2010/06/08/pulseless-massive-and-submassive-pe-role-of-lytics/). Newman's SMART EM on PE makes a pretty good argument against it. Although his review of the evidence belies a real paucity of data for lytics in massive PE.  Or anticoagulation for PE. Or anticoagulants for DVT.  I agree with close observation for decompensation and only then lysis.  The only submassive patient I could realistically see myself lysing is the constellation of high BNP, + trop, and RV strain on echo.
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